Research

What is NECTAR7 Niagen?

NECTAR7 delivers Niagen which is the first commercially available form of Nicotinamide Riboside (NR), offered in a capsule. The following is a step by step guide to get you learning.
What is Nicotinamide Riboside?
Niagen is Nicotinamide Riboside (or NR, a version of vitamin B3). By itself, Nicotinamide Riboside is not very useful. But once inside your body, it binds with proteins to create an enzyme known as nicotinamide adenine dinucleotide, or NAD+. Just remember this — “NR is a precursor to NAD+”
What is NAD+?
NAD+ can help mitochondria (the powerhouse inside your cells) generate energy and improve communication between other cells. In 2013 when a study conducted at Harvard University discovered that “raising NAD+ levels in old mice restored mitochondrial function to that of a young mouse.” More specifically, the tissue of the mice decreased in age significantly. And, “In human years, this would be like a 60-year-old converting to a 20-year-old in these specific areas.” Not so exciting until you read the next study completed by Dr. Charles Brenner.
What did Dr. Charles Brenner show the world?
Dr. Charles Brenner, a Biochemistry Professor at the University of Iowa Carver College of Medicine, recently completed a human clinical study showing a single dose of Niagen® increased NAD+ levels in human blood up to 2.7 times.

The NAD+ metabolomics analyses were performed in the laboratory of Dr. Charles Brenner, the Roy J. Carver Chair of Biochemistry and Professor of Internal Medicine at the University of Iowa. Dr. Charles Brenner, who was then a faculty member at Dartmouth College, discovered NR to be a vital precursor of NAD+, which is made available by nicotinamide riboside kinases (Nrks) that are conserved between yeast and humans. In 2007, Dr. Charles Brenner’s lab discovered a second pathway by which NR is converted to NAD+ and showed that NR can extend the lifespan of yeast cells by virtue of elevating NAD+ levels and increasing the activity of the NAD+-dependent Sir2 enzyme.

Mitochondrial Function

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL.

Cell. 2013 Dec 19;155(7):1624-38.

http://www.ncbi.nlm.nih.gov/pubmed/24360282

NAD+ and sirtuins in aging and disease.

Imai SI, Guarente L.

Trends Cell Biol. 2014 Apr 28. pii: S0962-8924(14)00063-4.

http://www.ncbi.nlm.nih.gov/pubmed/24786309

NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease.

Cerutti R, Pirinen E, Lamperti C, Marchet S, Sauve AA, Li W, Leoni V, Schon EA, Dantzer F, Auwerx J, Viscomi C, Zeviani M.

Cell Metab. 2014 May 7. pii: S1550-4131(14)00164-8.

http://www.ncbi.nlm.nih.gov/pubmed/24814483

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3.

Khan NA, Auranen M, Paetau I, Pirinen E, Euro L, Forsström S, Pasila L, Velagapudi V, Carroll CJ, Auwerx J, Suomalainen A.

EMBO Mol Med. 2014 Apr 6.

http://www.ncbi.nlm.nih.gov/pubmed/24711540

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.

Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J.

Cell Metab. 2012 Jun 6;15(6):838-47.

http://www.ncbi.nlm.nih.gov/pubmed/22682224

Cognitive Function

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models.

Gong B, Pan Y, Vempati P, Zhao W, Knable L, Ho L, Wang J, Sastre M, Ono K, Sauve AA, Pasinetti GM.

Neurobiol Aging. 2013 Jun;34(6):1581-8.

http://www.ncbi.nlm.nih.gov/pubmed/23312803

Neuropathies

Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy.

Sasaki Y, Araki T, Milbrandt J.

J Neurosci. 2006 Aug 16;26(33):8484-91.

http://www.ncbi.nlm.nih.gov/pubmed/16914673

Myopathies

NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy.

Goody MF, Kelly MW, Reynolds CJ, Khalil A, Crawford BD, Henry CA.

PLoS Biol. 2012;10(10):e1001409

http://www.ncbi.nlm.nih.gov/pubmed/23109907

Metabolism

Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

Yoshino J, Mills KF, Yoon MJ, Imai S.

Cell Metab. 2011 Oct 5;14(4):528-36.

http://www.ncbi.nlm.nih.gov/pubmed/21982712

NAD+ Biosynthesis

Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae.

Lu SP, Kato M, Lin SJ.

J Biol Chem. 2009 Jun 19;284(25):17110-9.

http://www.ncbi.nlm.nih.gov/pubmed/19416965

Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism.

Belenky P, Christensen KC, Gazzaniga F, Pletnev AA, Brenner C.

J Biol Chem. 2009 Jan 2;284(1):158-64.

http://www.ncbi.nlm.nih.gov/pubmed/19001417

Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C.

Cell. 2007 May 4;129(3):473-84.

http://www.ncbi.nlm.nih.gov/pubmed/17482543

Nicotinamide riboside kinase structures reveal new pathways to NAD+.

Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C.

PLoS Biol. 2007 Oct 2;5(10):e263.

http://www.ncbi.nlm.nih.gov/pubmed/17914902

Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans.

Bieganowski P, Brenner C.

Cell. 2004 May 14;117(4):495-502.

http://www.ncbi.nlm.nih.gov/pubmed/15137942

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.

Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Cantó C, Mottis A, Jo YS, Viswanathan M, Schoonjans K, Guarente L, Auwerx J.

Cell. 2013 Jul 18;154(2):430-41.

http://www.ncbi.nlm.nih.gov/pubmed/23870130

NAD+ as a signaling molecule modulating metabolism.

Cantó C, Auwerx J.

Cold Spring Harb Symp Quant Biol. 2011;76:291-8.

http://www.ncbi.nlm.nih.gov/pubmed/22345172

NAD⁺ metabolism: a therapeutic target for age-related metabolic disease.

Mouchiroud L, Houtkooper RH, Auwerx J.

Crit Rev Biochem Mol Biol. 2013 Jul-Aug;48(4):397-408.

http://www.ncbi.nlm.nih.gov/pubmed/23742622

Science & Research

The information and links below have been assembled for you to get familiar with the science community that is active in studying the many aspects of NAD+, Nicotinamide Riboside (NR), Niagen and more. Currently there are 42 Universities doing research with Niagen.

Human Study Report from Chromadex

http://investors.chromadex.com/phoenix.zhtml?c=212121&p=irol-newsArticle&ID=2078998.

Collaborative Human Clinical Study on NIAGEN(R) With the University of Colorado Boulder

http://investors.chromadex.com/phoenix.zhtml?c=212121&p=irol-newsArticle&ID=2060413

Scientific American Reports on Anti-Aging

http://blogs.scientificamerican.com/guest-blog/beyond-resveratrol-the-anti-aging-nad-fad/

Quest to Reverse Aging

http://www.smh.com.au/good-weekend/never-say-die-david-sinclairs-antiageing-quest-20150916-gjocnm.html

Dr. Joseph Maroon discussing Niagen®, head neurosurgeon for the Pittsburgh Steelers

http://pittsburgh.cbslocal.com/video/3304711-tips-to-staying-young/

Reviews

NAD+ and sirtuins in aging and disease.

Imai SI, Guarente L.

Trends Cell Biol. 2014 Apr 28. pii: S0962-8924(14)00063-4

http://www.ncbi.nlm.nih.gov/pubmed/24786309

Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection.

Chi Y, Sauve AA.

Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):657-61

http://www.ncbi.nlm.nih.gov/pubmed/24071780

Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition.

Bogan KL, Brenner C.

Annu Rev Nutr. 2008;28:115-30.

http://www.ncbi.nlm.nih.gov/pubmed/18429699

NAD+ and vitamin B3: from metabolism to therapies.

Sauve AA.

J Pharmacol Exp Ther. 2008 Mar;324(3):883-93.

http://www.ncbi.nlm.nih.gov/pubmed/18165311

NAD+ metabolism in health and disease.

Belenky P, Bogan KL, Brenner C.

Trends Biochem Sci. 2007 Jan;32(1):12-9. Epub 2006 Dec 11

http://www.ncbi.nlm.nih.gov/pubmed/17161604

Collagen Supplementation

Rodwell, V., Bender, D., Botham, K., Kennelly, P., and Weil, P. (2015).
Harper’s Illustrated Biochemistry. New York: McGraw Hill [distributor].

https://books.google.com/books/about/Harper_s_Illustrated_Biochemistry_28th_E.html?id=XSZKD1EdKBoC

Hashizume, O., Ohnishi, S., Mito, T., Shimizu, A., Iashikawa, K., Nakada, K., … & Okita, K.
(2015). Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-
associated mitochondrial respiration defects. Scientific reports, 5.

http://www.nature.com/articles/srep10434

Pyun, H. B., Kim, M., Park, J., Sakai, Y., Numata, N., Shin, J. Y., … & Hwang, J. K. (2012).
Effects of collagen tripeptide supplement on photoaging and epidermal skin barrier in UVB-
exposed hairless mice. Preventive nutrition and food science, 17(4), 245.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866733/

Kim, J. K., Lee, J. H., Bae, I. H., Seo, D. B., & Lee, S. J. (2011).
Beneficial effect of a collagen peptide supplement on the epidermal skin barrier. Korean Journal of Food Science and Technology, 43(4), 458-463.

https://www.researchgate.net/publication/280984256_Beneficial_Effect_of_a_Collagen_Peptide_Supplement_on_the_Epidermal_Skin_Barrier

Clark, K. L., Sebastianelli, W., Flechsenhar, K. R., Aukermann, D. F., Meza, F., Millard, R. L., … & Albert, A. (2008).
24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current medical research and opinion, 24(5), 1485-1496.

http://www.tandfonline.com/doi/abs/10.1185/030079908X291967

Schauss, A. G., Stenehjem, J., Park, J., Endres, J. R., & Clewell, A. (2012).
Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving osteoarthritis-related symptoms: A randomized, double-blind, placebo-controlled trial. Journal of agricultural and food chemistry, 60(16), 4096-4101.

http://www.ncbi.nlm.nih.gov/pubmed/22486722

Moskowitz, R. W. (2000, October).
Role of collagen hydrolysate in bone and joint disease. In Seminars in arthritis and rheumatism (Vol. 30, No. 2, pp. 87-99). WB Saunders.

http://www.semarthritisrheumatism.com/article/S0049-0172(00)56825-5/abstract